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Links for 2021-04-19

  • Genomics and epidemiology of P.1 SARS-CoV-2 lineage

    The numbers are in, in this _Science_ paper —

    Cases of SARS-CoV-2 infection in Manaus, Brazil, resurged in late 2020, despite previously high levels of infection. Genome sequencing of viruses sampled in Manaus between November 2020 and January 2021 revealed the emergence and circulation of a novel SARS-CoV-2 variant of concern. Lineage P.1, acquired 17 mutations, including a trio in the spike protein (K417T, E484K and N501Y) associated with increased binding to the human ACE2 receptor. Molecular clock analysis shows that P.1 emergence occurred around mid-November 2020 and was preceded by a period of faster molecular evolution. Using a two-category dynamical model that integrates genomic and mortality data, we estimate that P.1 may be 1.7–2.4-fold more transmissible, and that previous (non-P.1) infection provides 54–79% of the protection against infection with P.1 that it provides against non-P.1 lineages. Enhanced global genomic surveillance of variants of concern, which may exhibit increased transmissibility and/or immune evasion, is critical to accelerate pandemic responsiveness.

    (tags: p1 sars-cov-2 covid-19 epidemiology transmission science papers)

  • Bert Hubert on the Huawei/5G backdoor controversy

    Some context — European telcos no longer operate their equipment:

    As an icebreaker, [telco operators] were asked if they thought the Chinese could eavesdrop through “backdoors” in Huawei equipment. Every single hand went up. One of the bankers then asked, for balance, if they thought the US could access communications through key Cisco equipment. “All the hands went straight back up without hesitation” [….] In a modern telecommunications service provider, new equipment is deployed, configured, maintained and often financed by the vendor. Just to let that sink in, Huawei (and their close partners) already run and directly operate the mobile telecommunication infrastructure for over 100 million European subscribers. The host service provider often has no detailed insight in what is going on, and would have a hard time figuring this out through their remaining staff. Rampant outsourcing has meant that most local expertise has also left the company, willingly or unwillingly.
    (via ITS slack)

    (tags: telcos telecoms ops networking eu 5g china huawei nsa tapping)

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