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Links for 2022-09-21

  • Cache stampede

    Nice terminology — similar to the “thundering herd” problem seen in distributed systems. “A type of cascading failure that can occur when massively parallel computing systems with caching mechanisms come under very high load. This behaviour is sometimes also called dog-piling”

    (tags: caching distcomp caches cache-stampedes thundering-herd dogpiling failures cascading-failures load)

  • To boost or not to boost – by Eric Topol

    Where we are with COVID boosters:

    There’s ample evidence that a 3rd shot or 4th shot (1st or 2nd booster) will help provide important protection, and that is especially vital for people age 50+, with ample support for the recommendation for all age 12 and older to get boosters. The right question is about the 5th booster, for which there are no clinical data yet, but will likely extend a high level of protection against severe Covid. But 4 or 6 months isn’t going to cut it as a public health protection policy, as there will be further attrition of interest and uptake for boosters as we go forward. Fortunately, we’re declining in cases and will likely experience a fairly quiescent phase (further descent, no surge) with respect to infections and hospitalizations for the next couple of months until BA.2.75.2 gets legs (or an alternative BA.2 derivative). Now is the time to stop chasing SARS-CoV-2 and start mounting an aggressive get- ahead strategy. There’s the intertwined triad to contend with: more immune escape, more evidence of imprinting, and the inevitability of new variants that are already laying a foundation for spread. Enough of the booster after booster, shot-centric approach; it has been formidable, lifesaving, sickness-avoiding, and essential as a bootstrap, temporizing measure. Now we need to press on with innovation for more durable, palatable, and effective solutions. They are in our reach.

    (tags: covid-19 boosters vaccination omicron immunity)

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